Ttr, transthyretin

Ttr, transthyretin

• This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease. [provided by RefSeq, Mar 2010]

• (No alternate names found)
• NCBI Gene ID: 22139
• Species: Mus musculus (Mouse)
• UNIPROT ID#>>Q5M9K1
  UNIPROT ID#>>P07309
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transthyretin interacts with:

• ATP-binding cassette, sub-family A (ABC1), member 6
  cysteine-rich with EGF-like domains 2
  family with sequence similarity 169, member A
  Fanconi anemia, complementation group D2
  molybdenum cofactor sulfurase
  N-terminal EF-hand calcium binding protein 2
  OTU domain, ubiquitin aldehyde binding 1
  phytanoyl-CoA hydroxylase interacting protein
  suppression of tumorigenicity 13

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.