FGD1, FYVE, RhoGEF and PH domain containing 1

FGD1, FYVE, RhoGEF and PH domain containing 1

• This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of the faciogenital dysplasia in Aarskog-Scott syndrome and a syndromatic form of X-linked cognitive disability. [provided by RefSeq, Jul 2017]

• Gene Synonyms (AAS, FGDY, MRXS16, ZFYVE3, FYVE, RhoGEF and PH domain-containing protein 1, faciogenital dysplasia 1 protein, rho/Rac GEF, rho/Rac guanine nucleotide exchange factor FGD1, zinc finger FYVE domain-containing protein 3,)
• NCBI Gene ID: 2245
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P98174
  UNIPROT ID#>>A0A024R9Y5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

FYVE, RhoGEF and PH domain containing 1 interacts with:

• beta-transducin repeat containing E3 ubiquitin protein ligase
  engulfment and cell motility 1
  extended synaptotagmin 2
  F-box and leucine rich repeat protein 19
  gamma-glutamyl carboxylase
  integrator complex subunit 7
  MICAL like 2
  mitochondrial ribosomal protein L18
  phosphatidylinositol transfer protein membrane associated 1
  SH3 and PX domains 2A
  SH3 domain containing ring finger 1
  syntaxin 3
  transporter 2, ATP binding cassette subfamily B member

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.