CASC3, CASC3 exon junction complex subunit

CASC3, CASC3 exon junction complex subunit

• The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008]

• Gene Synonyms (protein CASC3, MLN 51, barentsz, cancer susceptibility 3, cancer susceptibility candidate 3, cancer susceptibility candidate gene 3 protein, metastatic lymph node 51, metastatic lymph node gene 51 protein, protein barentsz, BTZ, MLN51,)
• NCBI Gene ID: 22794
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O15234
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

CASC3 exon junction complex subunit interacts with:

• apolipoprotein B mRNA editing enzyme catalytic subunit 3D
  carbohydrate sulfotransferase 15
  CUGBP Elav-like family member 5
  cullin associated and neddylation dissociated 1
  G1 to S phase transition 2
  general transcription factor II E, polypeptide 2 (beta subunit)
  keratin associated protein 6-2
  LUC7 like
  LUC7 like 2, pre-mRNA splicing factor
  lysine demethylase 1B
  NKAP domain containing 1
  pleckstrin homology domain containing A4
  proline rich 11
  PTEN induced kinase 1
  PYM homolog 1, exon junction complex associated factor
  RNA binding motif protein 8a
  Smad nuclear interacting protein 1
  TNFAIP3 interacting protein 2
  transformer 2 alpha homolog
  UPF3A regulator of nonsense mediated mRNA decay
  UPF3B regulator of nonsense mediated mRNA decay

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.