CNKSR2, connector enhancer of kinase suppressor of Ras 2

CNKSR2, connector enhancer of kinase suppressor of Ras 2

• This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

• Gene Synonyms (CNK2, KSR2, MAGUIN, MRXSHG, connector enhancer of kinase suppressor of ras 2, CNK homolog protein 2, connector enhancer of KSR2, membrane-associated guanylate kinase-interacting protein,)
• NCBI Gene ID: 22866
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KPN2
  UNIPROT ID#>>Q8WXI2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

connector enhancer of kinase suppressor of Ras 2 interacts with:

• leucine rich repeat containing 7
  MOB kinase activator 3B
  SH3 and multiple ankyrin repeat domains 3
  SMAD specific E3 ubiquitin protein ligase 2
  TRAF2 and NCK interacting kinase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.