DENND5A, DENN domain containing 5A

DENND5A, DENN domain containing 5A

• This gene encodes a DENN-domain-containing protein that functions as a RAB-activating guanine nucleotide exchange factor (GEF). This protein catalyzes the conversion of GDP to GTP and thereby converts inactive GDP-bound Rab proteins into their active GTP-bound form. The encoded protein is recruited by RAB6 onto Golgi membranes and is therefore referred to as RAB6-interacting protein 1. This protein binds with RAB39 as well. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene are associated with early infantile epileptic encephalopathy-49. [provided by RefSeq, Feb 2017]

• Gene Synonyms (EIEE49, RAB6IP1, DENN domain-containing protein 5A, DENN/MADD domain containing 5A, RAB6 interacting protein 1, rab6-interacting protein 1,)
• NCBI Gene ID: 23258
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6IQ26
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DENN domain containing 5A interacts with:

• golgin A6 family like 9
  vir like m6A methyltransferase associated

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