UBR2, ubiquitin protein ligase E3 component n-recognin 2

UBR2, ubiquitin protein ligase E3 component n-recognin 2

• This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

• Gene Synonyms (C6orf133, bA49A4.1, dJ242G1.1, dJ392M17.3, E3 ubiquitin-protein ligase UBR2, RING-type E3 ubiquitin transferase UBR2, ubiquitin-protein ligase E3-alpha-2, ubiquitin-protein ligase E3-alpha-II,)
• NCBI Gene ID: 23304
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IWV8
  UNIPROT ID#>>B3KXG6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin protein ligase E3 component n-recognin 2 interacts with:

• ankyrin repeat and SOCS box containing 6
  cell division cycle 26
  coiled-coil domain containing 130
  dual specificity phosphatase 26
  dynein light chain roadblock-type 1
  egl-9 family hypoxia inducible factor 3
  epiplakin 1
  HEPACAM family member 2
  methyltransferase like 15
  methyltransferase like 2A
  mitochondrial ribosomal protein L50
  mitochondrial rRNA methyltransferase 1
  N(alpha)-acetyltransferase 11, NatA catalytic subunit
  p21 (RAC1) activated kinase 5
  par-6 family cell polarity regulator beta
  pleckstrin homology domain containing O2
  plexin domain containing 2
  pyruvate dehyrogenase phosphatase catalytic subunit 2
  regulator of G protein signaling 8
  RNA polymerase II subunit M
  shugoshin 1
  SIL1 nucleotide exchange factor
  sorting nexin 18
  SPARC related modular calcium binding 1
  testis expressed 33
  TIR domain containing adaptor protein
  tubulin tyrosine ligase-like family, member 7
  ubiquitin conjugating enzyme E2 O
  ubiquitin conjugating enzyme E2 Z
  UBX domain protein 1
  UBX domain protein 2B
  UBX domain protein 7
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.