ARHGEF18, Rho/Rac guanine nucleotide exchange factor 18

ARHGEF18, Rho/Rac guanine nucleotide exchange factor 18

• Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GEF family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2018]

• Gene Synonyms (P114-RhoGEF, RP78, SA-RhoGEF, p114RhoGEF, rho guanine nucleotide exchange factor 18, 114 kDa Rho-specific guanine nucleotide exchange factor, Rho-specific guanine nucleotide exchange factor p114, Rho/Rac guanine nucleotide exchange factor (GEF) 18, septin-associated RhoGEF,)
• NCBI Gene ID: 23370
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6ZSZ5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rho/Rac guanine nucleotide exchange factor 18 interacts with:

• pleckstrin homology domain containing A4
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.