CRB1, crumbs cell polarity complex component 1

CRB1, crumbs cell polarity complex component 1

• This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.[provided by RefSeq, Apr 2012]

• Gene Synonyms (protein crumbs homolog 1, crumbs 1, cell polarity complex component, crumbs family member 1, photoreceptor morphogenesis associated, LCA8, RP12,)
• NCBI Gene ID: 23418
• Species: Homo sapiens (Human)
• UNIPROT ID#>>F5H0L2
  UNIPROT ID#>>B7Z824
  UNIPROT ID#>>B7Z826
  UNIPROT ID#>>A8K118
  UNIPROT ID#>>P82279
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

crumbs cell polarity complex component 1 interacts with:

• erythrocyte membrane protein band 4.1 like 5
  mindbomb E3 ubiquitin protein ligase 1

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