SPO11, SPO11 initiator of meiotic double stranded breaks

SPO11, SPO11 initiator of meiotic double stranded breaks

• Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]

• Gene Synonyms (meiotic recombination protein SPO11, SPO11 meiotic protein covalently bound to DSB homolog, cancer/testis antigen 35, spermatogenesis associated 43, CT35, SPATA43, TOPVIA,)
• NCBI Gene ID: 23626
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y5K1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SPO11 initiator of meiotic double stranded breaks interacts with:

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