CEMIP2, cell migration inducing hyaluronidase 2

CEMIP2, cell migration inducing hyaluronidase 2

• This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss. [provided by RefSeq, Mar 2017]

• Gene Synonyms (cell surface hyaluronidase, transmembrane protein 2, TMEM2,)
• NCBI Gene ID: 23670
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R229
  UNIPROT ID#>>Q9UHN6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cell migration inducing hyaluronidase 2 interacts with:

• F-box protein 6
  N-acylethanolamine acid amidase
  OTU deubiquitinase with linear linkage specificity like
  sialic acid acetylesterase
  transmembrane protein 17
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.