TMEFF2, transmembrane protein with EGF like and two follistatin like domains 2

TMEFF2, transmembrane protein with EGF like and two follistatin like domains 2

• This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

• Gene Synonyms (tomoregulin-2, cancer/testis antigen family 120, member 2, hyperplastic polyposis protein 1, transmembrane protein TENB2, transmembrane protein with EGF-like and two follistatin-like domains, CT120.2, HPP1, TENB2, TPEF, TR, TR-2,)
• NCBI Gene ID: 23671
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UIK5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transmembrane protein with EGF like and two follistatin like domains 2 interacts with:

• argonaute RISC catalytic component 2
  NBPF member 19
  notch 2 N-terminal like A
  RIC3 acetylcholine receptor chaperone
  transmembrane protein 237
  UbiA prenyltransferase domain containing 1
  zinc finger DHHC-type palmitoyltransferase 15

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.