SPDEF, SAM pointed domain containing ETS transcription factor

SPDEF, SAM pointed domain containing ETS transcription factor

• The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

• Gene Synonyms (SAM pointed domain-containing Ets transcription factor, prostate epithelium-specific Ets transcription factor, prostate-derived Ets factor, prostate-specific Ets, PDEF, bA375E1.3,)
• NCBI Gene ID: 25803
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95238
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SAM pointed domain containing ETS transcription factor interacts with:

• enkurin domain containing 1
  FAM161 centrosomal protein B
  FAST kinase domains 1
  macrophage immunometabolism regulator
  myosin VC
  PR/SET domain 16
  protein arginine methyltransferase 8
  sorting nexin 20
  tetratricopeptide repeat domain 23

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.