PARS2, prolyl-tRNA synthetase 2, mitochondrial

PARS2, prolyl-tRNA synthetase 2, mitochondrial

• This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of proline to tRNA molecules. Mutations have been found in this gene in some patients with Alpers syndrome. [provided by RefSeq, Mar 2015]

• Gene Synonyms (probable proline--tRNA ligase, mitochondrial, proline tRNA ligase 2, mitochondrial (putative), prolyl-tRNA synthetase 2, mitochondrial (putative), EIEE75, MT-PRORS, proRS,)
• NCBI Gene ID: 25973
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q7L3T8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

prolyl-tRNA synthetase 2, mitochondrial interacts with:

• aldehyde dehydrogenase 16 family member A1
  coronin 1B
  egl-9 family hypoxia inducible factor 3
  heat shock protein family B (small) member 9
  leucyl-tRNA synthetase 1
  pleckstrin homology domain containing A4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.