LDLRAP1, low density lipoprotein receptor adaptor protein 1

LDLRAP1, low density lipoprotein receptor adaptor protein 1

• The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. [provided by RefSeq, Jul 2008]

• Gene Synonyms (low density lipoprotein receptor adapter protein 1, LDL receptor adaptor protein, autosomal recessive hypercholesterolemia protein, ARH, ARH1, ARH2, FHCB1, FHCB2, FHCL4,)
• NCBI Gene ID: 26119
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5SW96
  UNIPROT ID#>>B3KR97
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

low density lipoprotein receptor adaptor protein 1 interacts with:

• chromosome 6 open reading frame 58
  coiled-coil domain containing 85C
  DDB1 and CUL4 associated factor 16
  espin like
  neurolysin
  notochord homeobox
  ring finger and FYVE like domain containing E3 ubiquitin protein ligase
  STN1 subunit of CST complex

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.