AFF4, AF4/FMR2 family member 4

AFF4, AF4/FMR2 family member 4

• The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011]

• Gene Synonyms (AF4/FMR2 family member 4, ALL1-fused gene from chromosome 5q31 protein, major CDK9 elongation factor-associated protein, AF5Q31, CHOPS, MCEF,)
• NCBI Gene ID: 27125
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UHB7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

AF4/FMR2 family member 4 interacts with:

• CaM kinase like vesicle associated
  coiled-coil domain containing 8
  cyclin dependent kinase 15
  DENN domain containing 2D
  ELL associated factor 1
  ELL associated factor 2
  elongation factor for RNA polymerase II 3
  erythrocyte membrane protein band 4.1 like 5
  family with sequence similarity 9 member A
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  leucine rich repeat kinase 2
  mediator complex subunit 19
  myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1
  round spermatid basic protein 1
  trinucleotide repeat containing adaptor 6A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.