A1CF, APOBEC1 complementation factor

A1CF, APOBEC1 complementation factor

• Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

• Gene Synonyms (APOBEC1 complementation factor, APOBEC-1 stimulating protein, apo-B RNA editing protein, apobec-1 complementation factor (ACF) (ASP), ACF, ACF64, ACF65, APOBEC1CF, ASP,)
• NCBI Gene ID: 29974
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024QZI9
  UNIPROT ID#>>A0A024QZJ5
  UNIPROT ID#>>Q9NQ94
  UNIPROT ID#>>F8W9F8
  UNIPROT ID#>>A0A024QZM7
  UNIPROT ID#>>B4E1E3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

APOBEC1 complementation factor interacts with:

• chromosome 19 open reading frame 54
  chromosome 9 open reading frame 24
  cysteine rich tail 1
  docking protein 3
  kelch domain containing 7B
  methyltransferase like 27
  proteasome assembly chaperone 2
  proteasome assembly chaperone 3
  RIMS binding protein 3C
  transportin 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.