EFEMP2, EGF containing fibulin extracellular matrix protein 2

EFEMP2, EGF containing fibulin extracellular matrix protein 2

• A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]

• Gene Synonyms (EGF-containing fibulin-like extracellular matrix protein 2, EGF containing fibulin like extracellular matrix protein 2, FIBL-4, fibulin 4, mutant p53 binding protein 1, ARCL1B, FBLN4, MBP1, UPH1,)
• NCBI Gene ID: 30008
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R5G1
  UNIPROT ID#>>O95967
  UNIPROT ID#>>Q9H3D5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

EGF containing fibulin extracellular matrix protein 2 interacts with:

• ADAMTS like 4
  anaphase promoting complex subunit 11
  arrestin domain containing 3
  cation channel sperm associated 1
  chromosome 5 open reading frame 24
  coiled-coil domain containing 33
  cysteine rich DPF motif domain containing 1
  cysteine rich tail 1
  docking protein 7
  family with sequence similarity 110 member A
  family with sequence similarity 124 member B
  family with sequence similarity 90 member A1
  F-box and WD repeat domain containing 5
  FTO alpha-ketoglutarate dependent dioxygenase
  heat shock protein family A (Hsp70) member 12B
  HHIP like 1
  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
  inhibitor of CDK, cyclin A1 interacting protein 1
  keratin associated protein 10-8
  keratin associated protein 11-1
  keratin associated protein 12-2
  keratin associated protein 13-3
  keratin associated protein 19-5
  keratin associated protein 26-1
  keratin associated protein 3-2
  late cornified envelope 1A
  late cornified envelope 1C
  late cornified envelope 1E
  late cornified envelope 2C
  late cornified envelope 2D
  late cornified envelope 3A
  late cornified envelope 3C
  late cornified envelope 3D
  late cornified envelope 3E
  leucine rich repeat and Ig domain containing 1
  ligand of numb-protein X 1
  neurotrimin
  nuclear FMR1 interacting protein 2
  p53-induced death domain protein 1
  phospholipid scramblase 4
  proline rich 32
  RB associated KRAB zinc finger
  rhophilin Rho GTPase binding protein 1
  Rhox homeobox family member 2
  ring finger protein 138
  small glutamine rich tetratricopeptide repeat containing beta
  solute carrier family 25 member 48
  spermatogenesis associated 24
  spermatogenesis associated 3
  sprouty RTK signaling antagonist 4
  T cell leukemia homeobox 3
  THAP domain containing 7
  tribbles pseudokinase 3
  tripartite motif containing 42
  ubiquilin 4
  zinc finger protein 426
  zinc finger protein 558
  zinc finger protein 57
  zinc finger protein 581
  zinc finger protein 587
  zinc finger protein 670
  zinc finger protein 699
  zinc finger protein 768
  zinc finger protein 774
  zinc finger protein 837

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.