IGFBP7, insulin like growth factor binding protein 7

IGFBP7, insulin like growth factor binding protein 7

• This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

• Gene Synonyms (insulin-like growth factor-binding protein 7, IGF-binding protein 7, IGFBP-rP1, PGI2-stimulating factor, angiomodulin, prostacyclin-stimulating factor, tumor-derived adhesion factor, AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF,)
• NCBI Gene ID: 3490
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q16270
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

insulin like growth factor binding protein 7 interacts with:

• C-C motif chemokine ligand 21
  C-C motif chemokine ligand 5
  charged multivesicular body protein 3
  C-X-C motif chemokine ligand 10
  destrin, actin depolymerizing factor
  HNF1 homeobox A
  inhibin subunit beta A
  insulin
  RB binding protein 8, endonuclease
  reticulon 4
  syndecan 1
  vascular endothelial growth factor A
  Yes1 associated transcriptional regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.