IL4, interleukin 4

IL4, interleukin 4

• The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

• Gene Synonyms (interleukin-4, B cell growth factor 1, B_cell stimulatory factor 1, binetrakin, interleukin 4 variant 2, lymphocyte stimulatory factor 1, pitrakinra, BCGF-1, BCGF1, BSF-1, BSF1, IL-4,)
• NCBI Gene ID: 3565
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5FC01
  UNIPROT ID#>>D4HNR6
  UNIPROT ID#>>P05112
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

interleukin 4 interacts with:

• F-box protein 7
  interleukin 13 receptor subunit alpha 2
  interleukin 4 receptor
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.