KCNA4, potassium voltage-gated channel subfamily A member 4

KCNA4, potassium voltage-gated channel subfamily A member 4

• Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.[provided by RefSeq, Mar 2011]

• Gene Synonyms (HBK4, HK1, HPCN2, HUKII, KCNA4L, KCNA8, KV1.4, MCIDDS, PCN2, potassium voltage-gated channel subfamily A member 4, cardiac potassium channel, fetal skeletal muscle potassium channel, potassium channel 2, potassium channel, voltage gated shaker related subfamily A, member 4, rapidly inactivating potassium channel, shaker-related potassium channel Kv1.4, type A potassium channel, voltage-gated K(+) channel HuKII, voltage-gated potassium channel HBK4, voltage-gated potassium channel HK1, voltage-gated potassium channel subunit Kv1.4,)
• NCBI Gene ID: 3739
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P22459
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

potassium voltage-gated channel subfamily A member 4 interacts with:

• calcium/calmodulin dependent serine protein kinase
  DLG associated protein 1
  erbb2 interacting protein
  ligand of numb-protein X 1
  NDUFA4 mitochondrial complex associated like 2
  neuraminidase 1
  PATJ crumbs cell polarity complex component
  potassium channel regulator
  potassium voltage-gated channel subfamily A member 5
  potassium voltage-gated channel subfamily A regulatory beta subunit 2
  sirtuin 1
  spermidine/spermine N1-acetyltransferase 1
  SRC proto-oncogene, non-receptor tyrosine kinase
  syntrophin alpha 1
  syntrophin gamma 1

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