LIF, LIF interleukin 6 family cytokine

LIF, LIF interleukin 6 family cytokine

• The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

• Gene Synonyms (CDF, DIA, HILDA, MLPLI, leukemia inhibitory factor, D factor, cholinergic differentiation factor, differentiation inhibitory activity, differentiation-inducing factor, differentiation-stimulating factor, hepatocyte-stimulating factor III, human interleukin in DA cells, melanoma-derived LPL inhibitor,)
• NCBI Gene ID: 3976
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P15018
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

LIF interleukin 6 family cytokine interacts with:

• hematopoietic prostaglandin D synthase
  keratin associated protein 12-3
  LIF receptor subunit alpha
  neurocalcin delta

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.