CCDC88C, coiled-coil domain containing 88C

CCDC88C, coiled-coil domain containing 88C

• This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the dishevelled protein. Dishevelled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain. [provided by RefSeq, Jan 2013]

• Gene Synonyms (DAPLE, HKRP2, HYC1, KIAA1509, SCA40, protein Daple, Dvl-associating protein with a high frequency of leucine residues, hook-related protein 2, spinocerebellar ataxia 40,)
• NCBI Gene ID: 440193
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DZB8
  UNIPROT ID#>>Q9P219
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

coiled-coil domain containing 88C interacts with:

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