MYH7, myosin heavy chain 7

MYH7, myosin heavy chain 7

• Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CMD1S, CMH1, MPD1, MYHCB, SPMD, SPMM, myosin-7, cardiac muscle myosin heavy chain 7 beta, myHC-beta, myhc-slow, myopathy, distal 1, myosin 7, myosin heavy chain beta-subunit, myosin heavy chain slow isoform, myosin heavy chain, cardiac muscle beta isoform, myosin, heavy chain 7, cardiac muscle, beta, myosin, heavy polypeptide 7, cardiac muscle, beta, rhabdomyosarcoma antigen MU-RMS-40.7A,)
• NCBI Gene ID: 4625
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P12883
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

myosin heavy chain 7 interacts with:

• agrin
  A-kinase anchoring protein 17A
  ATPase H+ transporting V1 subunit D
  cell division cycle associated 8
  claspin
  clathrin interactor 1
  clavesin 2
  cyclin Q
  DISC1 scaffold protein
  DNA polymerase delta 1, catalytic subunit
  ecdysoneless cell cycle regulator
  Ecm29 proteasome adaptor and scaffold
  kelch like ECH associated protein 1
  KxDL motif containing 1
  nth like DNA glycosylase 1
  peroxiredoxin 5
  programmed cell death 6
  proteasome 26S subunit, non-ATPase 4
  protein phosphatase 3 regulatory subunit B, alpha
  Rho family GTPase 1
  rogdi atypical leucine zipper
  SEC61 translocon subunit beta
  sirtuin 6
  SIX homeobox 1
  spectrin alpha, non-erythrocytic 1
  synaptotagmin 3
  TATA-box binding protein associated factor 11
  TEA domain transcription factor 1
  TEA domain transcription factor 3
  TEA domain transcription factor 4
  threonyl-tRNA synthetase 3
  TLE family member 3, transcriptional corepressor
  transmembrane protein 260
  tropomyosin 2
  troponin I1, slow skeletal type
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  WW domain containing oxidoreductase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.