NFATC4, nuclear factor of activated T cells 4

NFATC4, nuclear factor of activated T cells 4

• This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

• Gene Synonyms (NF-AT3, NF-ATC4, NFAT3, nuclear factor of activated T-cells, cytoplasmic 4, T-cell transcription factor NFAT3, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4,)
• NCBI Gene ID: 4776
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14934
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nuclear factor of activated T cells 4 interacts with:

• ankyrin repeat domain 28
  lipin 1
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase 9
  neuroligin 3
  nuclear receptor subfamily 1 group I member 2
  protein phosphatase 3 catalytic subunit alpha
  protein phosphatase 3 catalytic subunit gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.