PAFAH2, platelet activating factor acetylhydrolase 2

PAFAH2, platelet activating factor acetylhydrolase 2

• This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. [provided by RefSeq, Jul 2008]

• Gene Synonyms (HSD-PLA2, platelet-activating factor acetylhydrolase 2, cytoplasmic, SD-PLA2, platelet-activating factor acetylhydrolase 2, 40kDa, serine-dependent phospholipase A2,)
• NCBI Gene ID: 5051
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q99487
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

platelet activating factor acetylhydrolase 2 interacts with:

• diablo IAP-binding mitochondrial protein
  GrpE like 1, mitochondrial
  isoleucyl-tRNA synthetase 2, mitochondrial
  prefoldin subunit 4
  single stranded DNA binding protein 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  ubiquitin like modifier activating enzyme 1

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