DEF6, DEF6 guanine nucleotide exchange factor

DEF6, DEF6 guanine nucleotide exchange factor

• DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008]

• Gene Synonyms (differentially expressed in FDCP 6 homolog, DEF-6, IRF4-binding protein, SWAP-70-like adaptor protein of T cells, IBP, SLAT, SWAP70L,)
• NCBI Gene ID: 50619
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H4E7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DEF6 guanine nucleotide exchange factor interacts with:

• autophagy related 16 like 1
  brain enriched guanylate kinase associated
  BRCA1/BRCA2-containing complex subunit 3
  chromosome 1 open reading frame 52
  chromosome alignment maintaining phosphoprotein 1
  coiled-coil domain containing 88B
  DDB1 and CUL4 associated factor 16
  dicarbonyl and L-xylulose reductase
  eukaryotic translation initiation factor 4E nuclear import factor 1
  golgin A6 family like 9
  golgin A6 family member A
  homeobox and leucine zipper encoding
  inhibitor of CDK, cyclin A1 interacting protein 1
  integrator complex subunit 2
  kelch repeat and BTB domain containing 6
  KIAA1328
  L3MBTL histone methyl-lysine binding protein 3
  PBX homeobox interacting protein 1
  RAS protein activator like 3
  regulator of chromosome condensation 2
  Rho GTPase activating protein 22
  Rho GTPase activating protein 42
  RNA binding motif protein 45
  TEPSIN adaptor related protein complex 4 accessory protein
  trinucleotide repeat containing adaptor 6C
  zinc finger protein 688

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.