INSIG2, insulin induced gene 2

INSIG2, insulin induced gene 2

• The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]

• Gene Synonyms (insulin-induced gene 2 protein, INSIG2 membrane protein, insulin induced protein 2, INSIG-2,)
• NCBI Gene ID: 51141
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y5U4
  UNIPROT ID#>>A0A024RAI2
  UNIPROT ID#>>B4DQ23
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

insulin induced gene 2 interacts with:

• abhydrolase domain containing 4, N-acyl phospholipase B
  cAMP responsive element binding protein 3 like 1
  complexin 4
  cytochrome b-245 chaperone 1
  family with sequence similarity 209 member A
  G protein-coupled receptor 152
  glutathione peroxidase 8 (putative)
  golgi membrane protein 1
  hydroxysteroid 17-beta dehydrogenase 13
  LHFPL tetraspan subfamily member 5
  membrane magnesium transporter 1
  ring finger protein 145
  sodium voltage-gated channel beta subunit 3
  solute carrier family 16 member 10
  transmembrane protein 14B
  transmembrane protein 237
  transmembrane protein 45B
  transmembrane protein 52B
  vacuolar ATPase assembly factor VMA21

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.