MARCHF2, membrane associated ring-CH-type finger 2

MARCHF2, membrane associated ring-CH-type finger 2

• MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]

• Gene Synonyms (E3 ubiquitin-protein ligase MARCHF2, E3 ubiquitin-protein ligase MARCH2, RING finger protein 172, RING-type E3 ubiquitin transferase MARCH2, RING-type E3 ubiquitin transferase MARCHF2, membrane associated ring finger 2, membrane-associated RING finger protein 2, membrane-associated RING-CH protein II, membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase, HSPC240, MARCH-II, MARCH2, RNF172,)
• NCBI Gene ID: 51257
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9P0N8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

membrane associated ring-CH-type finger 2 interacts with:

• cAMP responsive element binding protein 3 like 1
  ERGIC and golgi 3
  family with sequence similarity 209 member A
  fetal and adult testis expressed 1
  glutathione peroxidase 8 (putative)
  golgi associated PDZ and coiled-coil motif containing
  KASH domain containing 5
  leucine rich repeat containing G protein-coupled receptor 4
  low density lipoprotein receptor class A domain containing 1
  OTU deubiquitinase with linear linkage specificity like
  phospholipid phosphatase related 2
  serine rich single-pass membrane protein 1
  sodium voltage-gated channel beta subunit 3
  spectrin repeat containing nuclear envelope family member 4
  translocator protein 2
  transmembrane protein 106C
  transmembrane protein 179B
  transmembrane protein 52B
  transmembrane protein 86B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.