SPA17, sperm autoantigenic protein 17

SPA17, sperm autoantigenic protein 17

• This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]

• Gene Synonyms (sperm surface protein Sp17, cancer/testis antigen 22, sperm protein 17, CT22, SP17, SP17-1,)
• NCBI Gene ID: 53340
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15506
  UNIPROT ID#>>A0A172Q397
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sperm autoantigenic protein 17 interacts with:

• A-kinase anchoring protein 14
  EF-hand calcium binding domain 7
  ELL associated factor 1
  F-box protein 44
  myosin light chain 6B
  rhophilin associated tail protein 1
  rhophilin associated tail protein 1 like
  rhophilin associated tail protein 1B
  WD repeat domain 45B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.