TMX3, thioredoxin related transmembrane protein 3

TMX3, thioredoxin related transmembrane protein 3

• This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The canonical protein encoded by this gene has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This gene is expressed in many tissues but has its highest expression in heart and skeletal muscle. It is expressed in the retinal neuroepithelium and lens epithelium in the developing murine eye and haploinsufficiency of this gene in humans and zebrafish is associated with microphthalmia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]

• Gene Synonyms (protein disulfide-isomerase TMX3, protein disulfide isomerase family A, member 13, thioredoxin domain containing 10, thioredoxin domain-containing protein 10, PDIA13, TXNDC10,)
• NCBI Gene ID: 54495
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96JJ7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

thioredoxin related transmembrane protein 3 interacts with:

• cytochrome b5 type B
  dual specificity phosphatase 22
  egl-9 family hypoxia inducible factor 3
  limb development membrane protein 1 like
  pleckstrin homology domain containing A4
  tectonic family member 2
  unc-93 homolog B1, TLR signaling regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.