ERCC6L, ERCC excision repair 6 like, spindle assembly checkpoint helicase

ERCC6L, ERCC excision repair 6 like, spindle assembly checkpoint helicase

• This gene encodes a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF2) family of proteins, and contains a SNF2-like ATPase domain and a PICH family domain. One distinguishing feature of this SWI/SNF protein family member is that during interphase, the protein is excluded from the nucleus, and only associates with chromatin after the nuclear envelope has broken down. This protein is a DNA translocase that is thought to bind double-stranded DNA that is exposed to stretching forces, such as those exerted by the mitotic spindle. This protein associates with ribosomal DNA and ultra-fine DNA bridges (UFBs), fine structures that connect sister chromatids during anaphase at some sites such as fragile sites, telomeres and centromeres. This gene is required for the faithful segregation of sister chromatids during mitosis, and the ATPase activity of this protein required for the resolution of UFBs before cytokinesis. [provided by RefSeq, May 2017]

• Gene Synonyms (DNA excision repair protein ERCC-6-like, ATP-dependent helicase ERCC6-like, Plk1-interacting checkpoint helicase, SNF2/RAD54 family protein, excision repair cross-complementation group 6 like, excision repair cross-complementing rodent repair deficiency complementation group 6 - like, excision repair cross-complementing rodent repair deficiency, complementation group 6-like, excision repair protein ERCC6-like, tumor antigen BJ-HCC-15, PICH, RAD26L,)
• NCBI Gene ID: 54821
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q2NKX8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ERCC excision repair 6 like, spindle assembly checkpoint helicase interacts with:

• alanyl-tRNA synthetase domain containing 1
  caseinolytic mitochondrial matrix peptidase chaperone subunit B
  egl-9 family hypoxia inducible factor 3
  excision repair cross-complementing rodent repair deficiency complementation group 6 like
  limb development membrane protein 1 like
  midnolin
  N-acetylglucosamine kinase
  pleckstrin homology domain containing A4
  WD repeat and FYVE domain containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.