MRPS18A, mitochondrial ribosomal protein S18A

MRPS18A, mitochondrial ribosomal protein S18A

• Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

• Gene Synonyms (39S ribosomal protein S18a, mitochondrial, 28S ribosomal protein S18-3, mitochondrial, 28S ribosomal protein S18a, mitochondrial, 39S ribosomal protein S18-3, mitochondrial, mitochondrial large ribosomal subunit protein bS18a, mitochondrial large ribosomal subunit protein bS18m-A, mitochondrial large ribosomal subunit protein mL66, mitochondrial ribosomal protein S18-3, HumanS18b, MRP-S18-3, MRP-S18-a, MRPS18-3, S18bmt, S18mt-a,)
• NCBI Gene ID: 55168
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NVS2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitochondrial ribosomal protein S18A interacts with:

• catenin beta like 1
  LEO1 homolog, Paf1/RNA polymerase II complex component
  mitochondrial ribosomal protein L1
  mitochondrial ribosomal protein L10
  mitochondrial ribosomal protein L41
  mitochondrial ribosomal protein L47
  mitochondrial ribosomal protein L9
  mitochondrial ribosomal protein S5
  mitochondrial rRNA methyltransferase 1
  nucleolar protein 12
  pleckstrin homology domain containing A4
  WD repeat domain 61
  zinc finger protein 317

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.