PARL, presenilin associated rhomboid like

PARL, presenilin associated rhomboid like

• This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016]

• Gene Synonyms (PRO2207, PSARL, PSARL1, PSENIP2, RHBDS1, presenilins-associated rhomboid-like protein, mitochondrial, mitochondrial intramembrane-cleaving protease PARL, rhomboid 7 homolog 1,)
• NCBI Gene ID: 55486
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H300
  UNIPROT ID#>>C9JNP8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

presenilin associated rhomboid like interacts with:

• carbonic anhydrase 10
  egl-9 family hypoxia inducible factor 3
  ENAH actin regulator
  eukaryotic elongation factor 2 lysine methyltransferase
  glycosylated lysosomal membrane protein
  H2A clustered histone 21
  pleckstrin homology domain containing A4
  PTEN induced kinase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.