PLEKHG5, pleckstrin homology and RhoGEF domain containing G5

PLEKHG5, pleckstrin homology and RhoGEF domain containing G5

• This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this gene are associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

• Gene Synonyms (CMTRIC, DSMA4, GEF720, Syx, Tech, pleckstrin homology domain-containing family G member 5, NFkB activating protein, PH domain-containing family G member 5, guanine nucleotide exchange factor 720, novel PH domain-containing protein, pleckstrin homology domain containing, family G (with RhoGef domain) member 5, synectin-binding guanine exchange factor,)
• NCBI Gene ID: 57449
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O94827
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pleckstrin homology and RhoGEF domain containing G5 interacts with:

• G protein subunit beta 4
  ligand of numb-protein X 1
  ligand of numb-protein X 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.