SORT1, sortilin 1

SORT1, sortilin 1

• This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

• Gene Synonyms (sortilin, 100 kDa NT receptor, glycoprotein 95, neurotensin receptor 3, Gp95, LDLCQ6, NT3, NTR3,)
• NCBI Gene ID: 6272
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q99523
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sortilin 1 interacts with:

• 2'-5'-oligoadenylate synthetase like
  adhesion G protein-coupled receptor G7
  aprataxin
  ATP binding cassette subfamily A member 7
  BAR/IMD domain containing adaptor protein 2 like 1
  beta-secretase 1
  biogenesis of ribosomes BRX1
  BRICHOS domain containing 5
  bridging integrator 3
  C2 calcium dependent domain containing 5
  centromere protein V
  chromosome 2 open reading frame 69
  CMT1A duplicated region transcript 4
  cordon-bleu WH2 repeat protein like 1
  cornichon family AMPA receptor auxiliary protein 3
  DEAD-box helicase 51
  DExD/H-box helicase 60
  dicer 1, ribonuclease III
  DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
  DnaJ heat shock protein family (Hsp40) member A4
  egl-9 family hypoxia inducible factor 3
  essential meiotic structure-specific endonuclease 1
  FA complementation group M
  Fas associated factor family member 2
  F-box and leucine rich repeat protein 19
  fibronectin type III domain containing 3A
  forkhead box R1
  GC-rich promoter binding protein 1
  golgi associated, gamma adaptin ear containing, ARF binding protein 1
  golgi associated, gamma adaptin ear containing, ARF binding protein 2
  golgi associated, gamma adaptin ear containing, ARF binding protein 3
  GTF2I repeat domain containing 1
  importin 9
  interactor of little elongation complex ELL subunit 2
  intercellular adhesion molecule 5
  kelch domain containing 2
  keratin 75
  KIAA1191
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
  LEM domain nuclear envelope protein 2
  lemur tyrosine kinase 2
  limb development membrane protein 1 like
  LSM14A mRNA processing body assembly factor
  mediator complex subunit 13L
  MIA SH3 domain ER export factor 3
  mitochondrial ribosomal protein L24
  mitochondrial ribosomal protein L55
  mitochondrial rRNA methyltransferase 1
  MORC family CW-type zinc finger 2
  M-phase phosphoprotein 6
  MUS81 structure-specific endonuclease subunit
  NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
  nucleolar protein 6
  NudC domain containing 3
  palmdelphin
  phosphodiesterase 12
  poly(ADP-ribose) polymerase family member 9
  pseudopodium enriched atypical kinase 1
  RAB11 family interacting protein 5
  Rho GTPase activating protein 32
  ribosomal RNA processing 1B
  RNA binding motif protein 28
  serine and arginine rich splicing factor 2
  SET binding factor 2
  SH3 and PX domains 2B
  signal sequence receptor subunit 1
  signal transducing adaptor molecule
  sirtuin 5
  slingshot protein phosphatase 3
  solute carrier family 2 member 4
  solute carrier family 25 member 25
  sortilin related receptor 1
  sortilin related VPS10 domain containing receptor 1
  spectrin beta, non-erythrocytic 2
  synaptotagmin binding cytoplasmic RNA interacting protein
  T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
  talin 1
  tec protein tyrosine kinase
  terminal nucleotidyltransferase 4B
  thioredoxin domain containing 11
  transferrin
  transmembrane protein 9
  treacle ribosome biogenesis factor 1
  TRIO and F-actin binding protein
  tRNA splicing endonuclease subunit 2
  tubulin alpha 1c
  tubulin beta class I
  tyrosyl-tRNA synthetase 1
  ubiquitin specific peptidase 1
  ubiquitin specific peptidase 11
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 32
  UDP-glucose glycoprotein glucosyltransferase 2
  UDP-N-acetylglucosamine pyrophosphorylase 1
  UFM1 specific peptidase 2
  URB1 ribosome biogenesis homolog
  URB2 ribosome biogenesis homolog
  UTP15 small subunit processome component
  uveal autoantigen with coiled-coil domains and ankyrin repeats
  vir like m6A methyltransferase associated
  WW domain containing E3 ubiquitin protein ligase 2
  X-ray repair cross complementing 2
  zinc finger CCCH-type containing, antiviral 1
  zinc finger protein 768

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.