SCNN1B, sodium channel epithelial 1 subunit beta

SCNN1B, sodium channel epithelial 1 subunit beta

• Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome. [provided by RefSeq, Apr 2009]

• Gene Synonyms (amiloride-sensitive sodium channel subunit beta, amiloride-sensitive sodium channel subunit beta 1, beta-ENaC, beta-NaCH, epithelial Na(+) channel subunit beta, epithelial sodium channel beta-2 subunit, epithelial sodium channel beta-3 subunit, mutant sodium channel epithelial 1 beta subunit, nasal epithelial sodium channel beta subunit, nonvoltage-gated sodium channel 1 subunit beta, sodium channel epithelial 1 beta subunit, sodium channel, non-voltage-gated 1, beta subunit, sodium channel, nonvoltage-gated 1, beta, BESC1, ENaCb, ENaCbeta, LIDLS1, SCNEB,)
• NCBI Gene ID: 6338
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B2R812
  UNIPROT ID#>>P51168
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sodium channel epithelial 1 subunit beta interacts with:

• adaptor related protein complex 1 subunit mu 2
  COMM domain containing 10
  copper metabolism domain containing 1
  epsin 1
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
  hepatocyte growth factor-regulated tyrosine kinase substrate
  itchy E3 ubiquitin protein ligase
  NEDD4 like E3 ubiquitin protein ligase
  neurofascin
  serum/glucocorticoid regulated kinase 1
  sodium channel epithelial 1 subunit delta
  sodium channel epithelial 1 subunit gamma
  stress associated endoplasmic reticulum protein 1
  syntaxin 1A
  ubiquitin specific peptidase 2
  ubiquitin specific peptidase 8
  WW domain containing E3 ubiquitin protein ligase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.