CCL8, C-C motif chemokine ligand 8

CCL8, C-C motif chemokine ligand 8

• This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Sep 2014]

• Gene Synonyms (C-C motif chemokine 8, chemokine (C-C motif) ligand 8, monocyte chemoattractant protein 2, monocyte chemotactic protein 2, small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2), small-inducible cytokine A8, HC14, MCP-2, MCP2, SCYA10, SCYA8,)
• NCBI Gene ID: 6355
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P80075
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

C-C motif chemokine ligand 8 interacts with:

• atypical chemokine receptor 4
  C-C motif chemokine receptor 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.