ANO3, anoctamin 3

ANO3, anoctamin 3

• The protein encoded by this gene belongs to the TMEM16 family of predicted membrane proteins, that are also known as anoctamins. While little is known about the function of this gene, mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia. Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling. Studies in rat show that the rat ortholog of this protein interacts with, and modulates the activity of a sodium-activated potassium channel. Deletion of this gene caused increased pain sensitivity in the rat model system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

• Gene Synonyms (anoctamin-3, dystonia 23, transmembrane protein 16C (eight membrane-spanning domains), C11orf25, DYT23, DYT24, GENX-3947, TMEM16C,)
• NCBI Gene ID: 63982
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9BYT9
  UNIPROT ID#>>B7Z9B9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

anoctamin 3 interacts with:

• assembly factor for spindle microtubules
  TSC complex subunit 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.