SGSH, N-sulfoglucosamine sulfohydrolase

SGSH, N-sulfoglucosamine sulfohydrolase

• This gene encodes the enzyme sulfamidase; one of several enzymes involved in the lysosomal degradation of heparan sulfate. Mutations in this gene are associated with the lysosomal storage disease mucopolysaccaridosis IIIA, also known as Sanfilippo syndrome A, which results from impaired degradation of heparan sulfate. Transcripts of varying sizes have been reported but their biological validity has not been determined. [provided by RefSeq, Jun 2017]

• Gene Synonyms (N-sulphoglucosamine sulphohydrolase, heparan sulfate sulfatase, mucopolysaccharidosis type IIIA, sulfoglucosamine sulfamidase, sulphamidase, HSS, MPS3A, SFMD,)
• NCBI Gene ID: 6448
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P51688
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

N-sulfoglucosamine sulfohydrolase interacts with:

• DISC1 scaffold protein
  F-box protein 6
  limb development membrane protein 1 like
  N-acylethanolamine acid amidase
  peroxiredoxin 2
  S100 calcium binding protein A16
  sialic acid acetylesterase
  transmembrane protein 25

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.