SH3BP2, SH3 domain binding protein 2

SH3BP2, SH3 domain binding protein 2

• The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

• Gene Synonyms (SH3 domain-binding protein 2, Abl-SH3 binding protein 2, TNFAIP3 interacting protein 2, epididymis secretory sperm binding protein, 3BP-2, 3BP2, CRBM, CRPM, RES4-23,)
• NCBI Gene ID: 6452
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P78314
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SH3 domain binding protein 2 interacts with:

• cullin 7
  drebrin like
  exportin 1
  IKAROS family zinc finger 1
  linker for activation of T cells
  obscurin like cytoskeletal adaptor 1
  PDZ and LIM domain 7
  Rho GTPase activating protein 10
  ring finger protein 146
  SH3 domain containing kinase binding protein 1
  SH3 domain containing ring finger 1
  signal transducer and activator of transcription 3
  spleen associated tyrosine kinase
  SRC proto-oncogene, non-receptor tyrosine kinase
  tankyrase
  tankyrase 2
  transferrin
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  vav guanine nucleotide exchange factor 1
  vav guanine nucleotide exchange factor 2
  vav guanine nucleotide exchange factor 3
  zeta chain of T cell receptor associated protein kinase 70

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.