P2RY12, purinergic receptor P2Y12

P2RY12, purinergic receptor P2Y12

• The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

• Gene Synonyms (P2Y purinoceptor 12, ADP-glucose receptor, G-protein coupled receptor SP1999, Gi-coupled ADP receptor HORK3, P2Y12 platelet ADP receptor, purinergic receptor P2RY12, purinergic receptor P2Y, G-protein coupled, 12, putative G-protein coupled receptor, ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12, SP1999,)
• NCBI Gene ID: 64805
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H244
  UNIPROT ID#>>A8K7T1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

purinergic receptor P2Y12 interacts with:

• ADP ribosylation factor like GTPase 10
  ALG10 alpha-1,2-glucosyltransferase
  BRI3 binding protein
  ceramide synthase 5
  ceramide synthase 6
  chromosome 19 open reading frame 25
  cysteine rich with EGF like domains 1
  fat storage inducing transmembrane protein 2
  G protein-coupled receptor 89A
  gem nuclear organelle associated protein 6
  KIAA2013
  major facilitator superfamily domain containing 8
  peptidyl-tRNA hydrolase domain containing 1
  phosphatidylserine synthase 2
  RFT1 homolog
  ring finger protein 170
  serum amyloid A like 1
  solute carrier family 30 member 7
  transmembrane protein 161B
  transmembrane protein 164
  transmembrane protein with metallophosphoesterase domain
  tweety family member 3
  vitamin K epoxide reductase complex subunit 1 like 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.