Chd8, chromodomain helicase DNA binding protein 8

Chd8, chromodomain helicase DNA binding protein 8

• This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which is common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. In mammals, this gene has been shown to function in several processes including transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Knockout of this gene causes early embryonic lethality due to widespread apoptosis. Heterozygous loss of function mutations result in autism spectrum disorder-like behaviors that include increased anxiety, repetitive behavior, and altered social behavior. [provided by RefSeq, Dec 2016]

• (No alternate names found)
• NCBI Gene ID: 67772
• Species: Mus musculus (Mouse)
• UNIPROT ID#>>Q09XV5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

chromodomain helicase DNA binding protein 8 interacts with:

• CBY1 interacting BAR domain containing 1
  lysine (K)-specific methyltransferase 2A
  PHD finger protein 20
  retinoblastoma binding protein 5, histone lysine methyltransferase complex subunit
  TATA-box binding protein associated factor 1
  TRAF2 and NCK interacting kinase
  tubulin epsilon and delta complex 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.