TK2, thymidine kinase 2

TK2, thymidine kinase 2

• This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]

• Gene Synonyms (thymidine kinase 2, mitochondrial, thymidine kinase 2, mitochondrial thymidine kinase, mt-TK, MTDPS2, MTTK, PEOB3, SCA31,)
• NCBI Gene ID: 7084
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A5PLM0
  UNIPROT ID#>>Q8IZR3
  UNIPROT ID#>>B4E0Z4
  UNIPROT ID#>>B4DIW4
  UNIPROT ID#>>A4IF54
  UNIPROT ID#>>O00142
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

thymidine kinase 2 interacts with:

• anaphase promoting complex subunit 15
  catenin beta interacting protein 1
  dickkopf WNT signaling pathway inhibitor 1
  glutathione S-transferase kappa 1
  mitochondrial ribosomal protein L9
  tubulin tyrosine ligase-like family, member 7

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.