SLX1B, SLX1 homolog B, structure-specific endonuclease subunit

SLX1B, SLX1 homolog B, structure-specific endonuclease subunit

• This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene. [provided by RefSeq, Nov 2010]

• Gene Synonyms (structure-specific endonuclease subunit SLX1, GIY-YIG domain-containing protein 1, SLX1 structure-specific endonuclease subunit homolog B, GIYD2,)
• NCBI Gene ID: 79008
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9BQ83
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SLX1 homolog B, structure-specific endonuclease subunit interacts with:

• essential meiotic structure-specific endonuclease 1
  gem nuclear organelle associated protein 6
  MUS81 structure-specific endonuclease subunit
  PAXIP1 associated glutamate rich protein 1
  SLX1 homolog A, structure-specific endonuclease subunit
  SLX4 interacting protein
  SLX4 structure-specific endonuclease subunit
  SRA stem-loop interacting RNA binding protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.