TSEN34, tRNA splicing endonuclease subunit 34

TSEN34, tRNA splicing endonuclease subunit 34

• This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Oct 2009]

• Gene Synonyms (tRNA-splicing endonuclease subunit Sen34, CTD-3093M3.1, TSEN34 tRNA splicing endonuclease subunit, hsSen34, leukocyte receptor cluster (LRC) member 5, leukocyte receptor cluster member 5, tRNA-intron endonuclease Sen34, LENG5, PCH2C, SEN34, SEN34L,)
• NCBI Gene ID: 79042
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DT51
  UNIPROT ID#>>A0A024R4N9
  UNIPROT ID#>>E7EQB3
  UNIPROT ID#>>Q9BSV6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tRNA splicing endonuclease subunit 34 interacts with:

• basic leucine zipper transcription factor, ATF-like 3
  CLP1, cleavage and polyadenylation factor I subunit
  tRNA splicing endonuclease subunit 15
  tRNA splicing endonuclease subunit 2
  tRNA splicing endonuclease subunit 54

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.