CCN4, cellular communication network factor 4

CCN4, cellular communication network factor 4

• This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]

• Gene Synonyms (CCN family member 4, WISP1 3'UTR-associated RNA 1, WISP1 overlapping transcript 1 (non-protein coding), WNT1 induced secreted protein 1, WNT1 inducible signaling pathway protein 1, WISP1, WISP1-OT1, WISP1-UT1, WISP1c, WISP1i, WISP1tc,)
• NCBI Gene ID: 8840
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95388
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cellular communication network factor 4 interacts with:

• ring finger protein 123
  UDP-glucose glycoprotein glucosyltransferase 1

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