B4GALT5, beta-1,4-galactosyltransferase 5

B4GALT5, beta-1,4-galactosyltransferase 5

• This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2. [provided by RefSeq, Jul 2008]

• Gene Synonyms (beta-1,4-galactosyltransferase 5, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5, UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5, beta-1,4-GalT II, beta-1,4-GalT IV, beta-1,4-GalTase 5, beta-1.4-galactosyltransferase V, beta4-GalT IV, glucosylceramide beta-1,4-galactosyltransferase, lacCer synthase, lactosylceramide synthase, B4Gal-T5, BETA4-GALT-IV, beta4Gal-T5, beta4GalT-V, gt-V,)
• NCBI Gene ID: 9334
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43286
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

beta-1,4-galactosyltransferase 5 interacts with:

• family with sequence similarity 234 member B
  glycoprotein integral membrane 1
  interleukin 20 receptor subunit beta
  interleukin 27 receptor subunit alpha
  keratocan
  lipase H
  MGAT4 family member C
  neurexophilin 2
  solute carrier family 39 member 9
  synaptotagmin 12
  two pore segment channel 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.