AKAP5, A-kinase anchoring protein 5

AKAP5, A-kinase anchoring protein 5

• The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]

• Gene Synonyms (A-kinase anchor protein 5, A kinase (PRKA) anchor protein 5, A-kinase anchor protein 79 kDa, A-kinase anchoring protein 75/79, AKAP 79, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein, AKAP75, AKAP79, H21,)
• NCBI Gene ID: 9495
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P24588
  UNIPROT ID#>>Q6PG46
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

A-kinase anchoring protein 5 interacts with:

• CTD small phosphatase like
  derlin 1
  importin 4
  LUC7 like 3 pre-mRNA splicing factor
  mitochondrial ribosomal protein L43
  OTU deubiquitinase 6B
  RBMX like 1
  rhophilin associated tail protein 1
  rhophilin associated tail protein 1 like
  round spermatid basic protein 1 like
  sphingomyelin synthase 2
  transient receptor potential cation channel subfamily M member 8
  transient receptor potential cation channel subfamily V member 2
  transient receptor potential cation channel subfamily V member 3
  transient receptor potential cation channel subfamily V member 4
  transmembrane protein 17

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.