ADAMTS1, ADAM metallopeptidase with thrombospondin type 1 motif 1

ADAMTS1, ADAM metallopeptidase with thrombospondin type 1 motif 1

• This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]

• Gene Synonyms (A disintegrin and metalloproteinase with thrombospondin motifs 1, ADAM-TS 1, ADAM-TS1, ADAMTS-1, METH-1, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1, human metalloproteinase with thrombospondin type 1 motifs, C3-C5, METH1,)
• NCBI Gene ID: 9510
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UHI8
  UNIPROT ID#>>B2RB33
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ADAM metallopeptidase with thrombospondin type 1 motif 1 interacts with:

• ADAM metallopeptidase domain 32
  centrosomal protein 250
  dickkopf WNT signaling pathway inhibitor 3
  keratin 40
  keratin associated protein 10-8
  limb development membrane protein 1 like
  phospholipase A2 group XIIB
  pyrin and HIN domain family member 1
  serine protease 50
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.