PPP6R2, protein phosphatase 6 regulatory subunit 2

PPP6R2, protein phosphatase 6 regulatory subunit 2

• The protein encoded by this gene is a regulatory protein for the protein phosphatase-6 catalytic subunit. Together, these proteins act as a significant T-loop phosphatase for Aurora A, an essential mitotic kinase. Loss of function of either the regulatory or catalytic subunit of protein phosphatase-6 interferes with spindle formation and chromosome alignment. [provided by RefSeq, May 2017]

• Gene Synonyms (serine/threonine-protein phosphatase 6 regulatory subunit 2, SAPS domain family, member 2, KIAA0685, PP6R2, SAP190, SAPS2,)
• NCBI Gene ID: 9701
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O75170
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein phosphatase 6 regulatory subunit 2 interacts with:

• acyl-CoA dehydrogenase family member 11
  ankyrin repeat domain 28
  ankyrin repeat domain 28
  ankyrin repeat domain 44
  ankyrin repeat domain 52
  assembly factor for spindle microtubules
  calcyclin binding protein
  deleted in primary ciliary dyskinesia homolog (mouse)
  DNA cross-link repair 1C
  dual specificity phosphatase 13
  dynein cytoplasmic 1 light intermediate chain 1
  egl-9 family hypoxia inducible factor 3
  golgi reassembly stacking protein 1
  hook microtubule tethering protein 3
  huntingtin interacting protein K
  hypoxia inducible factor 1 subunit alpha inhibitor
  ilvB acetolactate synthase like
  mitochondrial E3 ubiquitin protein ligase 1
  MOB kinase activator 1A
  MOB kinase activator 1B
  myosin VC
  nuclear distribution C, dynein complex regulator
  PNKD metallo-beta-lactamase domain containing
  prefoldin subunit 6
  protein phosphatase 6 regulatory subunit 1
  protein phosphatase 6 regulatory subunit 3
  protein phosphatase 6, catalytic subunit
  RuvB like AAA ATPase 2
  saccharopine dehydrogenase (putative)
  SH3 domain containing GRB2 like, endophilin B2
  solute carrier family 26 member 6
  solute carrier family 27 member 2
  TANK binding kinase 1
  transmembrane protein 43
  tRNA methyltransferase 2 homolog A
  ubiquitin specific peptidase 49
  WD repeat domain 92
  zinc finger protein 574
  zinc finger protein 785

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.